A ONCE-DAILY ORAL JAK inhibitor indicated for the treatment of adults and pediatric patients 12+ years of age with refractory, moderate to severe atopic dermatitis whose disease is not adequately controlled with other systemic drug products, including biologics, or when use of those therapies are inadvisable.1

ONE PILL

ONCE-DAILY

DOSING1

RINVOQ® is the first oral JAK inhibitor indicated for pediatrics 12 years and up.

RINVOQ is an oral JAK inhibitor for refractory, moderate to severe AD1

Available in 2 dosage strengths1

  • For adults <65 years and pediatric patients 12+ years weighing at least 40 kg (88 lb), initiate treatment with 15 mg orally once-daily
    • If an adequate response is not achieved, consider increasing the dosage to 30 mg once-daily
    • Discontinue RINVOQ if an adequate response is not achieved with the 30 mg dose
    • Use the lowest effective dose needed to maintain response
  • For patients ≥65 years of age, patients receiving strong CYP3A4 inhibitors, and patients with severe renal impairment, the recommended dose of RINVOQ is 15 mg once-daily

Administration1

  • RINVOQ tablets should be taken orally with or without food
  • RINVOQ is an extended-release tablet, do not split, crush, or chew. Ensure tablet is swallowed whole

AD=atopic dermatitis.

RINVOQ® (upadacitinib) packaging.
  • Coadministration of RINVOQ with strong CYP3A4 inducers is not recommended
  • RINVOQ initiation is not recommended in patients with an absolute lymphocyte count (ALC) less than 500 cells/mm3, absolute neutrophil count (ANC) less than 1,000 cells/mm3, or hemoglobin level less than 8 g/dL
  • RINVOQ is not recommended for use in patients with severe hepatic impairment (Child-Pugh C)
  • RINVOQ treatment should be interrupted if a patient develops a serious infection until the infection is controlled
  • RINVOQ is not recommended for use in patients with end stage renal disease (eGFR <15 mL/min/1.73m2)
  • Interruption of dosing may be needed for management of laboratory abnormalities. See monitoring and treatment considerations

QUESTIONS ABOUT STARTING PATIENTS ON RINVOQ® (upadacitinib)?

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Want to learn about rapid skin clearance patients can see? In clinical studies
of RINVOQ, many patients achieved EASI 75 and vIGA 0/1 at Week 16.1

Itching to see more? See what patients experienced with RINVOQ in clinical trials.

Are your patients seeking treatment for the rash of atopic dermatitis?

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and stay on track with their prescribed treatment.

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